5-(benzyloxy)-2-methylpyridin-4(1H)-one → 5-hydroxy-2-methylpyridin-4(1H)-one

HRID 1187470

Reaktionsgleichung

Reaktionsgleichung von HRID 1187470
C([O:8][C:9]1[C:10](=[O:16])[CH:11]=[C:12]([CH3:15])[NH:13][CH:14]=1)C1C=CC=CC=1>CO.O.[Pd]>[OH:8][C:9]1[C:10](=[O:16])[CH:11]=[C:12]([CH3:15])[NH:13][CH:14]=1

Komponenten

5

Edukt 1

HCID 63247195-(benzyloxy)-2-methylpyridin-4(1H)-one

Produkt 1

HCID 6426495-hydroxy-2-methylpyridin-4(1H)-oneAusbeute 70,5 %

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

A solution of 5-benzyloxy-2-methyl-1H-pyridin-4-one (2 g, 9.29 mmol) in methanol (30 ml) and water (8 ml) was placed in a Parr bottle. 10% Pd/C was added and the mixture was hydrogenated at 50 psi for 3 hours. A bed of CELITE™ was placed on a sintered glass, and washed with 0.1N HCl and then water. The content in the Parr bottle was removed from the Parr hydrogenator and flushed with nitrogen. The solution was filtered under suction. The filtrate was evaporated to give a white solid (820 mg, 70% yield).

Aufarbeitung

  1. washwashed with 0.1N HCl
  2. customThe content in the Parr bottle was removed from the Parr hydrogenator
  3. customflushed with nitrogen
  4. filtrationThe solution was filtered under suction
  5. customThe filtrate was evaporated

Quellen und Nachweise

ORD-Eintrag
ord-2b44199cd4514f1d851c7ec6e91eaf55
Quelldatensatz
uspto-grants-2014_03
Patentnummer
US08673943B2

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