Hydrochloric Acid → HCID 178482234, Verbindung

HRID 1189640Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1189640
[F:1][C:2]([F:9])([F:8])[CH:3]1[CH2:7][CH2:6][NH:5][CH2:4]1.Cl.CCN(C(C)C)C(C)C.[F:20][C:21]([F:44])([F:43])[C@H:22]1[CH2:27][CH2:26][C@H:25]([NH:28][C:29](=[O:42])[C:30]2[CH:35]=[C:34]([N+:36]([O-:38])=[O:37])[C:33]([NH:39][CH3:40])=[CH:32][C:31]=2F)[CH2:24][CH2:23]1>O.CC#N>[F:20][C:21]([F:43])([F:44])[C@H:22]1[CH2:27][CH2:26][C@H:25]([NH:28][C:29](=[O:42])[C:30]2[CH:35]=[C:34]([N+:36]([O-:38])=[O:37])[C:33]([NH:39][CH3:40])=[CH:32][C:31]=2[N:5]2[CH2:6][CH2:7][CH:3]([C:2]([F:9])([F:8])[F:1])[CH2:4]2)[CH2:24][CH2:23]1

Komponenten

7

Edukt 4

HCID 313Hydrochloric AcidHCID 81531DiisopropylethylamineHCID 51521593-(Trifluoromethyl)pyrrolidineHCID 178482229HCID 178482229, Verbindung

Produkt 1

HCID 178482234HCID 178482234, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

A mixture of 3-trifluoromethyl-pyrrolidine×HCl (53 mg, 0.30 mmol), DIPEA (0.40 ml, 2.4 mmol), N-(trans-4-trifluoromethyl-cyclohexyl)-2-fluoro-4-methylamino-5-nitro-benzoic acid amide (100 mg, 0.28 mmol) and MeCN (2 mL) is stirred for 4.5 h at reflux. Then the mixture is diluted with water and the formed precipitate is filtered, washed with water and dried

Aufarbeitung

  1. temperatureat reflux
  2. filtrationthe formed precipitate is filtered
  3. washwashed with water
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-6ebbb829a94b4f8086bb4cb2742af89e
Quelldatensatz
uspto-grants-2014_03
Patentnummer
US08674113B2

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