2,4-Dichloro-5-fluoropyrimidine → 2-Chloro-5-fluoro-4-thiocyanopyrimidine
Reaktionsgleichung
[Cl:1][C:2]1[N:7]=[C:6](Cl)[C:5]([F:9])=[CH:4][N:3]=1.[S-:10][C:11]#[N:12].[K+]>C(O)=O>[Cl:1][C:2]1[N:7]=[C:6]([S:10][C:11]#[N:12])[C:5]([F:9])=[CH:4][N:3]=1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
In 50 ml of formic acid, a reaction of 10.0 g of 2,4-dichloro-5-fluoropyrimidine and 5.8 g of potassium thiocyanate was conducted at room temperature (20° C.) for 5 hours in a similar manner as Synthesis Example 1. Then, the reaction mixture was treated in a similar procedure as Synthesis Example 1, there was obtained a 68.0% yield of 2-chloro-5-fluoro-4-thiocyanopyrimidine, m.p. 103°-104° C.
Aufarbeitung
- customwas conducted at room temperature
- custom(20° C.)
- customfor 5 hours
- customas Synthesis Example 1
- additionThen, the reaction mixture was treated in a similar procedure as Synthesis Example 1
Quellen und Nachweise
- ORD-Eintrag
- ord-7ee0e4a201354c6e8f00fe3d06c35eae
- Quelldatensatz
- uspto-grants-1989_03
- Patentnummer
- US04814337
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