HCID 15588103, Verbindung → Methyl 4-chloro-3-hydroxythiophene-2-carboxylate
Reaktionsgleichung
Cl[C:2]1([C:9]([O:11][CH3:12])=[O:10])[C:6](=[O:7])[C:5]([Cl:8])=[CH:4][S:3]1>C(O)(=O)C.[Zn]>[Cl:8][C:5]1[C:6]([OH:7])=[C:2]([C:9]([O:11][CH3:12])=[O:10])[S:3][CH:4]=1Komponenten
4
Edukt 1
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Versuchsvorschrift
2,4-Dichloro-2-methoxycarbonylthiophene-3(2H)-one (60 mmol) in acetic acid (50 ml) was treated with metallic zinc (60 mmol) at room temperature for 18 hours. The solvent was removed under reduced pressure and the residue partitioned between water and ether. The organic phase was washed with water, dried with sodium sulphate and the solvent removed under reduced pressure to leave a solid which was crystallised from hexane m.p. 76°-77° C.
Aufarbeitung
- customThe solvent was removed under reduced pressure
- customthe residue partitioned between water and ether
- washThe organic phase was washed with water
- dry with materialdried with sodium sulphate
- customthe solvent removed under reduced pressure
- customto leave a solid which
- customwas crystallised from hexane m.p. 76°-77° C.
Quellen und Nachweise
- ORD-Eintrag
- ord-90b2f277360440e4b238740d48925f0d
- Quelldatensatz
- uspto-grants-1990_02
- Patentnummer
- US04904686
Notizen zur Reaktion
Wird geladen…