Sodium Methoxide → 2-Amino-4-methoxy-6-(4,5-dihydrothiazol-2-yl-thiomethyl)pyrimidine

HRID 1200224

Reaktionsgleichung

Reaktionsgleichung von HRID 1200224
[SH:1][C:2]1[S:3][CH2:4][CH2:5][N:6]=1.C[O-].[Na+].[NH2:10][C:11]1[N:16]=[C:15]([CH2:17]Cl)[CH:14]=[C:13]([O:19][CH3:20])[N:12]=1>CO.O>[NH2:10][C:11]1[N:12]=[C:13]([O:19][CH3:20])[CH:14]=[C:15]([CH2:17][S:1][C:2]2[S:3][CH2:4][CH2:5][N:6]=2)[N:16]=1

Komponenten

6

Edukt 3

HCID 10942334Sodium MethoxideHCID 138848154-(Chloromethyl)-6-methoxypyrimidin-2-amineHCID 178527880HCID 178527880, Verbindung

Produkt 1

HCID 200708312-Amino-4-methoxy-6-(4,5-dihydrothiazol-2-yl-thiomethyl)pyrimidine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

11.9 g of 4,5-dihydro-2-mercapto-thiazole are suspended in 100 ml of methanol, and to the suspension are added 18.0 g of 30% methanolic sodium methylate solution. To the formed clear solution are subsequently added 17.4 g of 2-amino-4-chloromethyl-6-methoxy-pyrimidine, and refluxing is carried out for 1 hours. After the solution has cooled, it is diluted with about 1 liter of water, and the product which precipitates is separated and dried. The yield is 22.5 g (88% of theory) of 2-amino-4-methoxy-6-(4,5-dihydrothiazol-2-yl-thiomethyl)-pyrimidine, m.p. 122°-124° C.

Aufarbeitung

  1. temperaturerefluxing
  2. temperatureAfter the solution has cooled
  3. customthe product which precipitates
  4. customis separated
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-0770c2aecf6f4f4e9a7e6d64a59f3ef5
Quelldatensatz
uspto-grants-1990_02
Patentnummer
US04904783

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