Acetone → 4-[(2-Chloro-6-methylpyrimidin-4-yl)oxy]-2,5-dimethylaniline
Reaktionsgleichung
[NH2:1][C:2]1[C:7]([CH3:8])=[CH:6][C:5]([OH:9])=[C:4]([CH3:10])[CH:3]=1.[OH-].[Na+].[Cl:13][C:14]1[N:19]=[C:18](Cl)[CH:17]=[CH:16][N:15]=1.[CH3:21]C(C)=O>O>[Cl:13][C:14]1[N:15]=[C:16]([O:9][C:5]2[C:4]([CH3:10])=[CH:3][C:2]([NH2:1])=[C:7]([CH3:8])[CH:6]=2)[CH:17]=[C:18]([CH3:21])[N:19]=1Komponenten
6
Edukt 4
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
A solution of 4.53 g (33 mmol) 4-amino-2,5-dimethylphenol and 1.44 g NaOH (2M) in 30 ml water were added dropwise to a solution of 4.89 g (30.0 mmol) of 2,4-dichloropyrimidine in 50 ml of acetone. The reaction mixture was stirred for 20 h at ambient temperature.
Quellen und Nachweise
- ORD-Eintrag
- ord-a317305e306944ef82b1ad5a3fc53986
- Quelldatensatz
- uspto-grants-2010_06
- Patentnummer
- US07727986B2
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