Sodium Hydroxide → 5-Phenyl-1,2-oxazol-3-amine

HRID 1241596Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1241596
[C:1]1([C:7]#[C:8][C:9]#[N:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl.[NH2:12][OH:13].[OH-].[Na+]>CCO.O>[NH2:10][C:9]1[CH:8]=[C:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[O:13][N:12]=1

Komponenten

6

Edukt 3

HCID 14798Sodium HydroxideHCID 963823-Phenyl-2-propynenitrileHCID 443297Hydroxyamine hydrochloride

Produkt 1

HCID 36207925-Phenyl-1,2-oxazol-3-amine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

To a stirred solution of 3-phenyl-2-propyne-nitrile (1.27 g, 0.01 mol, Step A) in EtOH (20 mL) was added at RT hydroxylamine hydrochloride (3.5 g, 0.05 mol) followed by 10% NaOH (28 mL). The exothermic reaction was stirred at RT 24 h, then diluted with H2O. The resulting precipitate was filtered off, washed with H2O and dried over P2O5 to afford 3-amino-5-phenylisoxazole as a white crystalline solid.

Aufarbeitung

  1. customThe exothermic reaction
  2. filtrationThe resulting precipitate was filtered off
  3. washwashed with H2O
  4. dry with materialdried over P2O5

Quellen und Nachweise

ORD-Eintrag
ord-2e390789c1c84e09a7cf468793ca3451
Quelldatensatz
uspto-grants-2006_10
Patentnummer
US07115617B2

Notizen zur Reaktion

Wird geladen…