Methacryloyl chloride → Aminoethyl methacrylate hydrochloride

Temperatur

110 °C

In a 500 mL three-neck flask equipped with a thermometer and a reflux condenser were placed 300 g of toluene and 60.0 g (0.62 mol) of ethanolamine hydrochloride, followed by heating to 110° C. with stirring. After the inner temperature reached 110° C., 77.1 g (0.74 mol) of methacryloyl chloride was added dropwise thereto over a period of 30 minutes. After completion of the dropwise addition, the mixture was continued to stir for further 3 hours and then cooled to 0° C. with stirring. The precipitated solid was collected by filtration and then the resulting solid was washed with 300 g of diisopropyl ether. The solid was collected by filtration and then dried under reduced pressure to obtain 85.2 g of 2-aminoethyl 2-methylacrylate hydrochloride.

1. customIn a 500 mL three-neck flask equipped with a thermometer and a reflux condenser
2. customreached 110° C.
3. additionAfter completion of the dropwise addition
4. stirringto stir for further 3 hours
5. temperaturecooled to 0° C.
6. stirringwith stirring
7. filtrationThe precipitated solid was collected by filtration
8. washthe resulting solid was washed with 300 g of diisopropyl ether
9. filtrationThe solid was collected by filtration
10. customdried under reduced pressure

ORD-Eintrag

ord-51c7103a3a9d4debb4a89eef46b8e5d7

Quelldatensatz

uspto-grants-2006_10

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US07115771B2