Butyl bromide → 4-Butoxy-3,5-dimethoxybenzoic acid

Temperatur

135 °C

Methyl syringate (10 g, 0.047 mol) and potassium carbonate (8.5 g, 0.061 mol) were stirred in acetophenone (100 mL) at 135° C. Butyl bromide (6.6 mL, 0.061 mol) was added dropwise over 1.5 h and the reaction was stirred over 18 h at 135° C. The reaction was cooled, filtered and the inorganic solids washed with acetone (20 mL). The combined filtrate was concentrated under high vacuum to give a red oil which was redissolved in ether (50 mL) and washed with 2N aqueous NaOH (2×10 mL) and water (3×10 mL). The organic layer was dried using anhydrous NaSO4 and the solvent removed under reduced pressure. The crude product was redissolved in methanol (250 mL) followed by addition of aqueous potassium hydroxide (44%, 20 mL). After heating at reflux for 2 h the reaction mixture was allowed to cool down to room temperature and left to rest over 18 h. The solvent was then concentrated under reduced pressure, the residue reconstituted in water (100 mL) and the resulting aqueous solution washed with ether (3×30 mL). The aqueous layer was acidified to pH=1 with 5N HCl and the precipitated product collected by filtration. The crude product was recrystallised from methanol to give 6.1 g, 51% yield of 4-butyloxy-3,5-dimethoxybenzoic acid as a colourless solid. 1H NMR (CDCl3) δ: 0.98 (t, J=5.1 Hz, 3H), 1.49 (m, 2H), 1.74 (m, 2H), 3.91 (s, 6H), 4.06 (t, J=5 Hz, 2H), 7.37 (s, 2H). MS m/z 255.4 (MH+).

1. temperatureThe reaction was cooled
2. filtrationfiltered
3. washthe inorganic solids washed with acetone (20 mL)
4. concentrationThe combined filtrate was concentrated under high vacuum
5. customto give a red oil which
6. washwashed with 2N aqueous NaOH (2×10 mL) and water (3×10 mL)
7. customThe organic layer was dried
8. customthe solvent removed under reduced pressure
9. dissolutionThe crude product was redissolved in methanol (250 mL)
10. additionfollowed by addition of aqueous potassium hydroxide (44%, 20 mL)
11. temperatureAfter heating
12. temperatureat reflux for 2 h the reaction mixture
13. temperatureto cool down to room temperature
14. waitleft
15. waitto rest over 18 h
16. concentrationThe solvent was then concentrated under reduced pressure
17. washthe resulting aqueous solution washed with ether (3×30 mL)
18. filtrationthe precipitated product collected by filtration
19. customThe crude product was recrystallised from methanol

ORD-Eintrag

ord-1348abf4b61e4b2a8c1527cc02ce9c17

Quelldatensatz

uspto-grants-2006_10

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US07126027B2