Allylamine → 2-Allylamino-4-dodecylamino-6-nitroquinazoline

HRID 1250599

Reaktionsgleichung

Reaktionsgleichung von HRID 1250599
Cl[C:2]1[N:11]=[C:10]([NH:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH3:24])[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([N+:25]([O-:27])=[O:26])[CH:8]=2)[N:3]=1.[CH2:28]([NH2:31])[CH:29]=[CH2:30]>O>[CH2:28]([NH:31][C:2]1[N:11]=[C:10]([NH:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH3:24])[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([N+:25]([O-:27])=[O:26])[CH:8]=2)[N:3]=1)[CH:29]=[CH2:30]

Komponenten

4

Edukt 2

HCID 7853AllylamineHCID 183265162-Chloro-4-dodecylamino-6-nitroquinazoline

Produkt 1

HCID 183265482-Allylamino-4-dodecylamino-6-nitroquinazolineAusbeute 93,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

To 170 mg (0.44 mmol) of 2-chloro-4-dodecylamino-6-nitroquinazoline was added 1.70 ml (22.66 mmol) of allylamine, and then the resulting mixture was stirred at room temperature overnight. After water was added to the reaction solution, crystals thus precipitated were filtered to give 170 mg (93.4%) of the title compound.

Aufarbeitung

  1. customthus precipitated
  2. filtrationwere filtered

Quellen und Nachweise

ORD-Eintrag
ord-46e3260cc7e241ce9c3303d32471a74b
Quelldatensatz
uspto-grants-2002_01
Patentnummer
US06339089B2

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