Bromine → 7-Bromothieno[3,2-d]pyrimidine-2,4(1h,3h)-dione

HRID 1250688Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1250688
[NH:1]1[C:6]2[CH:7]=[CH:8][S:9][C:5]=2[C:4](=[O:10])[NH:3][C:2]1=[O:11].[Br:12]Br>C(O)(=O)C>[Br:12][C:7]1[C:6]2[NH:1][C:2](=[O:11])[NH:3][C:4](=[O:10])[C:5]=2[S:9][CH:8]=1

Komponenten

4

Edukt 2

HCID 24408BromineHCID 7059273Thieno(3,2-d)pyrimidine-2,4(1H,3H)-dione

Produkt 1

HCID 183264277-Bromothieno[3,2-d]pyrimidine-2,4(1h,3h)-dioneAusbeute 56,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

To 250 ml of a solution of 7.31 g (52.2 mmol) of thieno[3,2-d]pyrimidine-2,4(1H,3H)-dione in acetic acid was added 25.0 g (156 mmol) of bromine at room temperature, followed by heating at 80° C. for 2 hours. After completion of the reaction, the solvent was distilled off under reduced pressure. Ice water was added to the residue, followed by filtering out crystals thus precipitated to give 7.24 g (yield: 56.2%) of the title compound.

Aufarbeitung

  1. customAfter completion of the reaction
  2. distillationthe solvent was distilled off under reduced pressure
  3. additionIce water was added to the residue
  4. filtrationby filtering out crystals
  5. customthus precipitated

Quellen und Nachweise

ORD-Eintrag
ord-949a025329c74fa99e685c2a1ed55aef
Quelldatensatz
uspto-grants-2002_01
Patentnummer
US06339089B2

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