Acetone Cyanohydrin → HCID 18323946, Verbindung

HRID 1251370Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1251370
[O-]S([O-])(=O)=O.[Mg+2].[CH3:7][C:8]([N:10](C)C)=O.[OH:13][CH:14]1[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]1.[S:20]1[CH2:25][CH2:24]C(=O)[CH2:22][CH2:21]1.CC(C)(O)C#N>>[OH:13][CH:14]1[CH2:19][CH2:18][N:17]([C:7]2([C:8]#[N:10])[CH2:24][CH2:25][S:20][CH2:21][CH2:22]2)[CH2:16][CH2:15]1

Komponenten

6

Edukt 5

HCID 6406Acetone CyanohydrinHCID 24083Sulfuric acid magnesium salt (1:1)HCID 31374DimethylacetamideHCID 66173Tetrahydrothiopyran-4-oneHCID 79341Piperidin-4-ol

Produkt 1

HCID 18323946HCID 18323946, Verbindung

Versuchsvorschrift

It is prepared from MgSO4 (7.2 g, 60 mmoles), DMA (2.62 g, 30 mmoles), 4-hydroxy-piperidine (3.03 g, 20 mmoles), tetrahydro-4H-thiopyran-4-one (2.32 g, 20 mmoles) and acetone cyanhydrin (1.7 g, 20 mmoles). After treatment of the reaction, a white solid is obtained (4.7 g) which is crystallized from anhydrous ether. In this way, white crystals are obtained (3.6 g, 79%). M.p.=79-81° C.

Aufarbeitung

  1. customAfter treatment of the reaction
  2. customa white solid is obtained (4.7 g) which
  3. customis crystallized from anhydrous ether
  4. customIn this way, white crystals are obtained (3.6 g, 79%)

Quellen und Nachweise

ORD-Eintrag
ord-eacb37ce01b34d108084f991eea0e370
Quelldatensatz
uspto-grants-2002_01
Patentnummer
US06342511B1

Notizen zur Reaktion

Wird geladen…