Phosphorus tribromide → 3-Fluoro-4-(methylsulphonyl)benzyl bromide

HRID 1254900Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1254900
[F:1][C:2]1[CH:3]=[C:4]([CH2:12]O)[CH:5]=[CH:6][C:7]=1[S:8]([CH3:11])(=[O:10])=[O:9].P(Br)(Br)[Br:15]>C(OCC)C.O>[Br:15][CH2:12][C:4]1[CH:5]=[CH:6][C:7]([S:8]([CH3:11])(=[O:10])=[O:9])=[C:2]([F:1])[CH:3]=1

Komponenten

5

Edukt 2

HCID 24614Phosphorus tribromideHCID 672190853-Fluoro-4-(methylsulphonyl)benzyl alcohol

Produkt 1

HCID 672190653-Fluoro-4-(methylsulphonyl)benzyl bromide

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

To a stirred suspension of (3-fluoro-4-methanesulfonyl-phenyl)-methanol (0.269 g, 1.31 mmol) in diethyl ether (5 ml) under an inert atmosphere of Argon is added dropwise phosphorus tribromide (46 μl, 0.434 mmol). After stirring at room temperature overnight, the reaction mixture is diluted with water (2 ml) and the diethyl ether layer separated. This organic portion is placed over NaOH pellets and after 20 minutes, is used as a reagent in solution in diethyl ether.

Aufarbeitung

  1. customthe diethyl ether layer separated
  2. waitThis organic portion is placed over NaOH pellets and after 20 minutes

Quellen und Nachweise

ORD-Eintrag
ord-ef5ace8d54f3449a913d26916b6f86c6
Quelldatensatz
uspto-grants-2013_06
Patentnummer
US08455645B2

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