1-Butanol → HCID 178433424, Verbindung

HRID 1255912Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1255912
Cl[C:2]1[N:7]=[C:6]([CH3:8])[N:5]=[C:4]([NH2:9])[C:3]=1[NH2:10].[CH3:11][C:12](=O)[C:13](=O)[CH3:14].C([OH:21])CCC>CCOCC>[CH3:8][C:6]1[NH:5][C:4]2[C:3]([C:2](=[O:21])[N:7]=1)=[N:10][C:13]([CH3:14])=[C:12]([CH3:11])[N:9]=2

Komponenten

5

Edukt 3

HCID 2631-ButanolHCID 650ButanedioneHCID 5941456-Chloro-2-methylpyrimidine-4,5-diamine

Produkt 1

HCID 178433424HCID 178433424, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel

Reaktionsbedingungen

Temperatur
77.5 °C

Versuchsvorschrift

A mixture of 6-chloro-2-methylpyrimidine-4,5-diamine (3.2 g, 20 mmol) and 2,3-butanedione (3.6 g, 42 mmol) in n-butanol (40 mL) was stirred at 75-80° C. for 1 h. After cooling, the reaction was diluted with Et2O (50 mL) and the solid collected by suction filtration. This was dried in vacuo affording, 2,6,7-trimethylpteridin-4(1H)-one (3.9 g), as a gold powder which was used in the next step without further purification.

Aufarbeitung

  1. temperatureAfter cooling
  2. filtrationthe solid collected by suction filtration
  3. customThis was dried in vacuo
  4. customaffording
  5. custom2,6,7-trimethylpteridin-4(1H)-one (3.9 g), as a gold powder which was used in the next step without further purification

Quellen und Nachweise

ORD-Eintrag
ord-df84f7e9adf64644998898bfbc6ad2c8
Quelldatensatz
uspto-grants-2013_06
Patentnummer
US08461164B2

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