Tert-Butylamine → N-tert-butyl-2-nitro-4-(trifluoromethyl)aniline

HRID 1256622Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1256622
F[C:2]1[CH:7]=[CH:6][C:5]([C:8]([F:11])([F:10])[F:9])=[CH:4][C:3]=1[N+:12]([O-:14])=[O:13].CN1CCCC1=O.[C:22]([NH2:26])([CH3:25])([CH3:24])[CH3:23]>O>[C:22]([NH:26][C:2]1[CH:7]=[CH:6][C:5]([C:8]([F:11])([F:10])[F:9])=[CH:4][C:3]=1[N+:12]([O-:14])=[O:13])([CH3:25])([CH3:24])[CH3:23]

Komponenten

5

Edukt 3

HCID 6385Tert-ButylamineHCID 13387N-methyl-2-pyrrolidoneHCID 677784-Fluoro-3-nitrobenzotrifluoride

Produkt 1

HCID 2736447N-tert-butyl-2-nitro-4-(trifluoromethyl)anilineAusbeute 81,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

To a mixture of 5.22 g of 4-fluoro-3-nitro-benzo trifluoride and 25 ml of N-methylpyrrolidone was added 3.88 g of tert-butylamine, and the mixture was stirred for 2 hours at room temperature. The reaction mixture was poured into water, the deposited solid was collected by filtration. This solid was washed with water, then, dried under reduced pressure, to obtain 5.35 g of N-tert-butyl-2-nitro-4-trifluoromethylaniline.

Aufarbeitung

  1. filtrationthe deposited solid was collected by filtration
  2. washThis solid was washed with water
  3. customdried under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-5b34e1fa7dc04e48989dd2b8aea57fee
Quelldatensatz
uspto-grants-2013_06
Patentnummer
US08461181B2

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