Pyridine → 3-Chloro-5-(trifluoromethyl)picolinaldehyde oxime

HRID 1259083

Reaktionsgleichung

Reaktionsgleichung von HRID 1259083
[Cl:1][C:2]1[C:3]([CH:12]=O)=[N:4][CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=1.Cl.[NH2:15][OH:16].N1C=CC=CC=1>C(O)C.C(OCC)(=O)C.O>[Cl:1][C:2]1[C:3]([CH:12]=[N:15][OH:16])=[N:4][CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=1

Komponenten

7

Edukt 3

HCID 1049PyridineHCID 443297Hydroxyamine hydrochlorideHCID 220187903-Chloro-5-(trifluoromethyl)picolinaldehyde

Produkt 1

HCID 7182493-Chloro-5-(trifluoromethyl)picolinaldehyde oxime

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 702EthanolLösungsmittelHCID 962WaterLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

A solution of 3-chloro-5-(trifluoromethyl)picolinaldehyde (1.0 eq.), hydroxylamine hydrochloride (5.0 eq.), and pyridine (4.0 eq.) in ethanol was heated to 95° C. and stirred for 1 hour. The reaction was cooled to room temperature and diluted with ethyl acetate and water. The organic layer was washed with brine, water, dried over anhydrous MgSO4, and concentrated en vacuo to give a solid that was carried onto the next step without further purification.

Aufarbeitung

  1. washThe organic layer was washed with brine, water
  2. dry with materialdried over anhydrous MgSO4
  3. concentrationconcentrated en vacuo
  4. customto give a solid
  5. customthat was carried onto the next step without further purification

Quellen und Nachweise

ORD-Eintrag
ord-14c141f09dad42bc8fae973638191d19
Quelldatensatz
uspto-grants-2013_06
Patentnummer
US08466167B2

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