Lithium Hydroxide → Methylsuccinic acid

HRID 1260407

Reaktionsgleichung

Reaktionsgleichung von HRID 1260407
[CH3:1][CH:2]([CH2:7][C:8]([O:10]C)=[O:9])[C:3]([O:5]C)=[O:4].[OH-].[Li+]>O1CCCC1.O>[CH3:1][CH:2]([CH2:7][C:8]([OH:10])=[O:9])[C:3]([OH:5])=[O:4]

Komponenten

5

Edukt 2

HCID 3939Lithium HydroxideHCID 15350Butanedioic acid, 2-methyl-, 1,4-dimethyl ester

Produkt 1

HCID 10349Methylsuccinic acid

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 8028TetrahydrofuranLösungsmittel

Reaktionsbedingungen

Temperatur
40 °C

Versuchsvorschrift

Commercially available dimethyl methylsuccinate (1.57 g, 9.8 mmol) was dissolved in a 3:1 mixed solvent of tetrahydrofuran and water, and lithium hydroxide (4 g, 98 mmol) was added and stirred for 2 days at 40° C. under reflux. After completion of the reaction was confirmed by TLC, the residue was distilled under reduced pressure to afford the title compound.

Aufarbeitung

  1. additionwas added
  2. temperatureunder reflux
  3. distillationthe residue was distilled under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-5c1c95c30a16424cb4d6a70811034722
Quelldatensatz
uspto-grants-2013_06
Patentnummer
US08470836B2

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