Phenyl chloroformate → Phenyl (1-phenyl-1H-pyrazol-5-yl)carbamate

HRID 1260471Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1260471
[C:1]1([N:7]2[C:11]([NH2:12])=[CH:10][CH:9]=[N:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:13]1([O:19][C:20](Cl)=[O:21])[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>ClCCCl.C(Cl)Cl>[C:1]1([N:7]2[C:11]([NH:12][C:20](=[O:21])[O:19][C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)=[CH:10][CH:9]=[N:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Komponenten

5

Edukt 2

HCID 15891Phenyl chloroformateHCID 700061-Phenylpyrazol-5-ylamine

Produkt 1

HCID 57925698Phenyl (1-phenyl-1H-pyrazol-5-yl)carbamate

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 111,2-DichloroethaneLösungsmittelHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

1-Phenyl-1H-pyrazol-5-amine (1 eq) was dissolved in DCE (0.1M), phenylchloroformate (1.1 eq) was added. The reaction was stirred 1 h, then diluted with DCM and washed with water and brine, dried and concentrated under reduced pressure to afford the product in quantitave yield.

Aufarbeitung

  1. washwashed with water and brine
  2. customdried
  3. concentrationconcentrated under reduced pressure
  4. customto afford the product in quantitave yield

Quellen und Nachweise

ORD-Eintrag
ord-282fa14689f945139d04cf3c2dee1b2e
Quelldatensatz
uspto-grants-2013_06
Patentnummer
US08470823B2

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