Phosphorus tribromide → 5-(Bromomethyl)-1-methyl-1H-benzotriazole

HRID 1260657Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1260657
P(Br)(Br)[Br:2].[CH3:5][N:6]1[C:10]2[CH:11]=[CH:12][C:13]([CH2:15]O)=[CH:14][C:9]=2[N:8]=[N:7]1>C(OCC)C.O>[Br:2][CH2:15][C:13]1[CH:12]=[CH:11][C:10]2[N:6]([CH3:5])[N:7]=[N:8][C:9]=2[CH:14]=1

Komponenten

5

Edukt 2

HCID 24614Phosphorus tribromideHCID 2776552(1-methyl-1H-1,2,3-benzotriazol-5-yl)methanol

Produkt 1

HCID 27954185-(Bromomethyl)-1-methyl-1H-benzotriazole

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

Phosphorus tribromide (0.230 ml, 2.45 mmol) is added to a stirred solution of (1-methyl-1H-1,2,3-benzotriazole-5-yl)methanol (0.4 g, 2.45 mmol) in diethyl ether (25 ml) under an inert atmosphere of Argon. After stirring overnight at room temperature, the reaction mixture is diluted with water (5 ml) and stirred vigorously for 10 minutes. The organic portion is separated, washed with water (2×5 ml), brine (2×5 ml) and concentrated in vacuo to yield the titled product which is used crude in the next step. (MH+ 226).

Aufarbeitung

  1. stirringstirred vigorously for 10 minutes
  2. customThe organic portion is separated
  3. washwashed with water (2×5 ml), brine (2×5 ml)
  4. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-68dc7baab7654b5d9086a695af0b34e3
Quelldatensatz
uspto-grants-2013_06
Patentnummer
US08470848B2

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