Formic Acid → Methyl 3-Formamidyl-2-methyl-4-methylsulfanylbenzoate

HRID 1263402Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1263402
[NH2:1][C:2]1[C:3]([CH3:14])=[C:4]([CH:9]=[CH:10][C:11]=1[S:12][CH3:13])[C:5]([O:7][CH3:8])=[O:6].[CH:15](O)=[O:16]>C(OC(=O)C)(=O)C>[CH:15]([NH:1][C:2]1[C:3]([CH3:14])=[C:4]([CH:9]=[CH:10][C:11]=1[S:12][CH3:13])[C:5]([O:7][CH3:8])=[O:6])=[O:16]

Komponenten

4

Edukt 2

HCID 284Formic AcidHCID 18616042Methyl 3-amino-2-methyl-4-methylsulfanylbenzoate

Produkt 1

HCID 86758893Methyl 3-Formamidyl-2-methyl-4-methylsulfanylbenzoate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 7918Acetic AnhydrideLösungsmittel

Versuchsvorschrift

At 40° C., 4.75 g of methyl 3-amino-2-methyl-4-methylsulfanylbenzoate (0.05 mol) were added a little at a time to a mixture of 30 ml of acetic anhydride and 2.2 g of formic acid (0.05 mol). After 5 h, the solution was allowed to cool and poured into ice-water, and the mixture was extracted exhaustively with methylene chloride. The organic phases were washed and dried, and the solvent was subsequently removed. Yield: 4.7 g (0.044 mol).

Aufarbeitung

  1. temperatureto cool
  2. extractionthe mixture was extracted exhaustively with methylene chloride
  3. washThe organic phases were washed
  4. customdried
  5. customthe solvent was subsequently removed

Quellen und Nachweise

ORD-Eintrag
ord-7c259bcd7d5f46efb7af8313d7eae164
Quelldatensatz
uspto-grants-2003_04
Patentnummer
US06541423B1

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