Cesium carbonate → Methyl O-(3'-amino-1,1'-biphenyl-3-yl)-N-triphenylmethyl-L-serinate

HRID 1265219Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1265219
C1([As](C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.Br[C:21]1[CH:22]=[C:23]([O:27][CH2:28][C@@H:29]([C:50]([O:52][CH3:53])=[O:51])[NH:30][C:31]([C:44]2[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=2)([C:38]2[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=2)[C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)[CH:24]=[CH:25][CH:26]=1.S(O)(O)(=O)=O.[NH2:59][C:60]1[CH:61]=[C:62](B(O)O)[CH:63]=[CH:64][CH:65]=1.NC1C=C(B(O)O)C=CC=1.C(=O)([O-])[O-].[Cs+].[Cs+]>COCCOC.O.C1(C)C=CC=CC=1>[NH2:59][C:60]1[CH:65]=[C:64]([C:21]2[CH:26]=[CH:25][CH:24]=[C:23]([O:27][CH2:28][C@@H:29]([C:50]([O:52][CH3:53])=[O:51])[NH:30][C:31]([C:38]3[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=3)([C:44]3[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=3)[C:32]3[CH:33]=[CH:34][CH:35]=[CH:36][CH:37]=3)[CH:22]=2)[CH:63]=[CH:62][CH:61]=1

Komponenten

8

Edukt 4

HCID 10796Cesium carbonateHCID 11773TriphenylarsineHCID 11329766Methyl O-(3-bromophenyl)-N-triphenylmethyl-L-serinateHCID 162111393-Aminophenylboronic Acid Hemisulfate

Produkt 1

HCID 11353040Methyl O-(3'-amino-1,1'-biphenyl-3-yl)-N-triphenylmethyl-L-serinate

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 962WaterLösungsmittelHCID 1140TolueneLösungsmittelHCID 80711,2-DimethoxyethaneLösungsmittel

Versuchsvorschrift

Triphenyl arsine (0.31 g, 1.0 mmol, 0.1 equiv) and dichloro-bis(triphenylphosphine)-palladium(II) (0.35 g, 0.50 mmol, 0.05 equiv) were stirred under an argon atmosphere in DME (dimethoxy ethane; 56 mL) at rt for 30 min. Methyl O-(3-bromophenyl)-N-triphenylmethyl-L-serinate (Example 1) (5.16 g, 10.0 mmol, 1.0 equiv) and 3-amino phenyl boronic acid hemisulfate (2.2 g, 6.0 mmol, 1.2 equiv) were added as solids, followed by a 2M aqueous solution of cesium carbonate (15.0 mL, 30.0 mmol, 3 equiv). The reaction mixture was stirred for 3 h at rt and partioned between toluene and water. The organic layer was separated and dried over sodium sulfate. After filtration and evaporation of the solvents in vacuuo the crude product was purified by chromatography on SiO2 (gradient: toluene to toluene/-ethanol 97:3) Yield: 7.3 g, 39.0%. 1H NMR (CDCl3, 200 MHz) δ 7.65-7.40 (m, 10H); 7.25-7.12 (m, 11H); 6.97 (d, 2H); 4.70 (dd, 1H); 4.7 (dd, 1H); 3.75-3.65 (m, 3H); 3.24 (s, 3H); 2.90 (d, 1H). MS (DCI/NH3) 546 (M+NH4+), 529 (M+H); 234 (CPh3).

Aufarbeitung

  1. customThe organic layer was separated
  2. dry with materialdried over sodium sulfate
  3. filtrationAfter filtration and evaporation of the solvents in vacuuo the crude product
  4. customwas purified by chromatography on SiO2 (gradient: toluene to toluene/-ethanol 97:3) Yield: 7.3 g, 39.0%

Quellen und Nachweise

ORD-Eintrag
ord-cce0981db5b44fe0bf6c13efc2754a9f
Quelldatensatz
uspto-grants-2003_04
Patentnummer
US06545029B2

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