Water → 2-Fluorobenzoic acid

HRID 1266629Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1266629
[C:1](=[O:4])([O-])[O-:2].[Na+].[Na+].Br[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[F:14].O.C12(PC34CC(CC3)CC4)CC(CC1)CC2>O1CCOCC1.[OH-].[Na+].C(OCC)C.[Cl-].[Cl-].C(#N)C1C=CC=CC=1.C(#N)C1C=CC=CC=1.[Pd+2]>[F:14][C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=1[C:1]([OH:2])=[O:4]

Komponenten

9

Edukt 4

HCID 962WaterHCID 10340Sodium CarbonateHCID 612591-Bromo-2-fluorobenzeneHCID 22679109HCID 22679109, Verbindung

Produkt 1

HCID 99352-Fluorobenzoic acid

Reagenzien, Katalysatoren, Lösungsmittel 4

HCID 10271322Benzonitrile;dichloropalladiumKatalysatorHCID 3283Diethyl EtherLösungsmittelHCID 14798Sodium HydroxideLösungsmittelHCID 312751,4-DioxaneLösungsmittel2×

Reaktionsbedingungen

Temperatur
120 °C

Versuchsvorschrift

Sodium carbonat (3.34 g, 32 mmols), 1-bromo-2-fluorobenzene (3.68 g, 21 mmols), water (1.1 g, 63 mmol) and 40 ml of dioxane are placed in a glass autoclave. The autoclave is rinsed with nitrogen and heated to 120° C. A solution of palladium bis(benzonitrile) dichloride (161 mg, 0.42 mmols) and dinorbornylphosphine (420 mg, 1.90 mmols) in 2 ml of dioxane (prepared under argon) is added, and then 6 bars CO are applied. After 16 hours at 135° C., the mixture is allowed to cool. The reaction mixture is taken up in sodium hydroxide solution and diethyl ether. The aqueous phase is separated and acidified with concentrated hydrochloric acid. The title compound precipitates in the form of colourless crystals. Yield of title compound: 1.6 g (54%).

Aufarbeitung

  1. washThe autoclave is rinsed with nitrogen
  2. temperatureto cool
  3. customThe aqueous phase is separated
  4. customThe title compound precipitates in the form of colourless crystals

Quellen und Nachweise

ORD-Eintrag
ord-7be8b53f32a14368b3f3c99aa42c334f
Quelldatensatz
uspto-grants-2003_04
Patentnummer
US06548684B2

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