Sodium Hydroxide → Emetine

HRID 1267097Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1267097
[CH3:1][CH2:2][C@@H:3]1[C@@H:16]([CH2:17][C@H:18]2[NH:27][CH2:26][CH2:25][C:24]3[C:19]2=[CH:20][C:21]([O:30][CH3:31])=[C:22]([O:28][CH3:29])[CH:23]=3)[CH2:15][C@@H:14]2[N:5]([CH2:6][CH2:7][C:8]3[C:13]2=[CH:12][C:11]([O:32][CH3:33])=[C:10]([O:34][CH3:35])[CH:9]=3)[CH2:4]1.Cl.Cl.[OH-].[Na+]>O>[CH3:1][CH2:2][C@@H:3]1[C@@H:16]([CH2:17][C@H:18]2[NH:27][CH2:26][CH2:25][C:24]3[CH:23]=[C:22]([O:28][CH3:29])[C:21]([O:30][CH3:31])=[CH:20][C:19]2=3)[CH2:15][C@@H:14]2[N:5]([CH2:6][CH2:7][C:8]3[CH:9]=[C:10]([O:34][CH3:35])[C:11]([O:32][CH3:33])=[CH:12][C:13]=32)[CH2:4]1

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 3068143Emetine dihydrochloride

Produkt 1

HCID 10219EmetineAusbeute 92,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

5 g of Emetine dihydrochloride (5H2O) was dissolved in 100 ml of water and thereto was added 0.1 N sodium hydroxide to adjust pH to 7.5. The solution was extracted three times with 100 ml of ether. The removal of ether gave about 4 g of emetine (emetine).

Aufarbeitung

  1. extractionThe solution was extracted three times with 100 ml of ether
  2. customThe removal of ether

Quellen und Nachweise

ORD-Eintrag
ord-8b2fd1c099a445e49198718c7c782c6b
Quelldatensatz
uspto-grants-2003_04
Patentnummer
US06552035B2

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