Sodium Chlorate → HCID 68803290, Verbindung

HRID 1270719Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1270719
[CH2:1]1[CH2:6][CH2:5][CH:4]([CH2:7][C:8]([NH:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[O:9])[CH2:3][CH2:2]1.[Cl:17]([O-])(=O)=O.[Na+].S(=O)(O)[O-].[Na+]>Cl.C(O)(=O)C.O>[Cl:17][CH:2]1[CH2:3][CH:4]([CH2:7][C:8]([NH:10][C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=2)=[O:9])[CH2:5][CH2:6][CH2:1]1

Komponenten

7

Edukt 3

HCID 516902Sodium ChlorateHCID 880922HCID 880922, VerbindungHCID 23665763Sodium Bisulfite

Produkt 1

HCID 68803290HCID 68803290, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 176Acetic AcidLösungsmittelHCID 313Hydrochloric AcidLösungsmittelHCID 962WaterLösungsmittel2×

Versuchsvorschrift

4-Cyclohexylacetanilide (24 g, 110 mmol) is dissolved in a mixture of concentrated HCl (25 mL) and acetic acid (75 mL). The mixture is cooled in an ice bath and a solution of sodium chlorate (NaClO3, 7.5 g, 70 mmol) in water (30 mL) is added via a dropping funnel. The reaction is allowed to warm to room temperature and then poured into saturated sodium bisulfite solution (500 mL). The solid which forms is isolated by filtration and subsequently washed first with water (500 mL) and then a mixture of hexanes/Et2O (10:1, 500 mL). The resulting solid is air dried to yield 2-chloro-4-cyclohexylacetanilide (m.p. 110–112° C.).

Aufarbeitung

  1. temperatureThe mixture is cooled in an ice bath
  2. customdried

Quellen und Nachweise

ORD-Eintrag
ord-5799d97428b14d8faba4b4ac81245470
Quelldatensatz
uspto-grants-2007_04
Patentnummer
US07202364B2

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