Hydrochloric Acid → 1,4-Bis(3-aminopropyl)piperazine Glutaric Dialdehyde

HRID 1271821

Reaktionsgleichung

Reaktionsgleichung von HRID 1271821
[NH2:1][CH2:2][CH2:3][CH2:4][N:5]1[CH2:10][CH2:9][N:8]([CH2:11][CH2:12][CH2:13][NH2:14])[CH2:7][CH2:6]1.[CH2:15]([CH2:19][CH:20]=[O:21])[CH2:16][CH:17]=[O:18].Cl>O>[NH2:14][CH2:13][CH2:12][CH2:11][N:8]1[CH2:7][CH2:6][N:5]([CH2:4][CH2:3][CH2:2][NH2:1])[CH2:10][CH2:9]1.[CH2:15]([CH2:19][CH:20]=[O:21])[CH2:16][CH:17]=[O:18]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 3485GlutaraldehydeHCID 816291,4-Bis(3-aminopropyl)piperazine

Produkt 1

HCID 1317263401,4-Bis(3-aminopropyl)piperazine Glutaric DialdehydeAusbeute 14 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel2×

Versuchsvorschrift

1,4-Bis(3-aminopropyl)piperazine (206 μL, 0.998 mmol, Aldrich Chemical Company) was taken up in 5.0 mL H2O. Glutaric dialdehyde (206 μL, 0.998 mmol, Aldrich Chemical Company) was added and the solution was stirred at room temperature. After 30 min, an additional portion of H2O was added (20 mL), and the mixture neutralized with 6 N HCl to pH 7, resulting in a red solution. Dialysis against H2O (3×3 L, 12,000–14,000 MWCO) and lyophilization afforded 38 mg (14%) of the copolymer.

Aufarbeitung

  1. customresulting in a red solution
  2. customDialysis against H2O (3×3 L, 12,000–14,000 MWCO) and lyophilization

Quellen und Nachweise

ORD-Eintrag
ord-492a519d0c24430daba05ab030e65ad3
Quelldatensatz
uspto-grants-2007_04
Patentnummer
US07208314B2

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