Bromine → 2-Butanone, 1-bromo-4-chloro-3,3-dimethyl-

134.5 g (1 mol) of 1-chloro-2,2-dimethyl-butan-3-one were dissolved in 500 ml of ether. 51 ml (1 mol) of bromine were added dropwise at room temperature, with slight cooling, at a rate such that the bromine was steadily consumed. The solution was then stirred into 1,000 ml of ice-water and the organic phase was separated off, rinsed with 250 ml of water, dried over sodium sulphate and distilled. 169 g (80% of theory) of 1-bromo-4-chloro-3,3-dimethyl-butan-2-one of boiling point 95°-106° C./13 mm Hg were obtained.

1. customwas steadily consumed
2. customthe organic phase was separated off
3. washrinsed with 250 ml of water
4. dry with materialdried over sodium sulphate
5. distillationdistilled

ORD-Eintrag

ord-26c0cb7ed0254c2fa331b82a740c8c02

Quelldatensatz

uspto-grants-1981_03

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US04255434