Hydrogen Bromide → 4-(3-Bromofuran-2-yl)-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)pyrazole

HRID 1274346

Reaktionsgleichung

Reaktionsgleichung von HRID 1274346
[C:1]([C:3]1[C:7]([CH:8]([OH:18])[C:9]#[C:10][CH:11](OCC)OCC)=[CH:6][N:5]([C:19]2[C:24]([Cl:25])=[CH:23][C:22]([C:26]([F:29])([F:28])[F:27])=[CH:21][C:20]=2[Cl:30])[N:4]=1)#[N:2].[BrH:31].O.CCOCC>O1CCOCC1>[Br:31][C:9]1[CH:10]=[CH:11][O:18][C:8]=1[C:7]1[C:3]([C:1]#[N:2])=[N:4][N:5]([C:19]2[C:24]([Cl:25])=[CH:23][C:22]([C:26]([F:27])([F:28])[F:29])=[CH:21][C:20]=2[Cl:30])[CH:6]=1

Komponenten

6

Edukt 4

HCID 260Hydrogen BromideHCID 962WaterHCID 3283Diethyl EtherHCID 221208993-Cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-(4,4-diethoxy-1-hydroxybut-2-ynyl)pyrazole

Produkt 1

HCID 99116334-(3-Bromofuran-2-yl)-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)pyrazole

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

To a stirred solution of 3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-(4,4-diethoxy-1-hydroxybut-2-ynyl)pyrazole (0.04 g) in dioxane (1 ml) was added dropwise at room temperature hydrobromic acid (0.04 g). After 30 minutes the reaction mixture was poured into water (10 ml) and ether (10 ml). The organic layer was separated, dried (MgSO4) and evaporated. Recrystallisation from ether/hexane gave the title compound as a pale brown solid, m.p. 99-101° C.

Aufarbeitung

  1. customThe organic layer was separated
  2. dry with materialdried (MgSO4)
  3. customevaporated
  4. customRecrystallisation from ether/hexane

Quellen und Nachweise

ORD-Eintrag
ord-dadf621e28264c99bf5815c02c3458c9
Quelldatensatz
uspto-grants-2000_12
Patentnummer
US06156782

Verknüpfte Notizen

Wird geladen…