Sodium Carbonate → 3-Isoxazolamine, 5-(1,1-dimethylethyl)-

HRID 127715

Reaktionsgleichung

Reaktionsgleichung von HRID 127715
[C:1]([CH2:7][C:8]#[N:9])(=[O:6])[C:2]([CH3:5])([CH3:4])[CH3:3].C(=O)([O-])[O-].[Na+].[Na+].S(O)(O)(=O)=O.[NH2:21]O>O>[NH2:9][C:8]1[CH:7]=[C:1]([C:2]([CH3:5])([CH3:4])[CH3:3])[O:6][N:21]=1

Komponenten

5

Edukt 3

HCID 10340Sodium CarbonateHCID 108871Pentanenitrile, 4,4-dimethyl-3-oxo-HCID 159255Hydroxylamine, sulfate (1:1)

Produkt 1

HCID 1714733-Isoxazolamine, 5-(1,1-dimethylethyl)-Ausbeute 124,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A suspension of pivaloylacetonitrile (12.52 g), sodium carbonate (8.74 g) and water (200 ml) is stirred and mixed with hydroxylamine sulfate (9.03 g) at 25° C. pH 7.11. The reaction mixture is treated as in Example 2 to give 3-amino-5-t-butylisoxazole (12.01 g). Yield, 85.7%. Purity, 95.8%.

Aufarbeitung

  1. additionThe reaction mixture is treated as in Example 2

Quellen und Nachweise

ORD-Eintrag
ord-fb681df70af54e46886ea03fbdfbd7f2
Quelldatensatz
uspto-grants-1981_03
Patentnummer
US04256899

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