Ethanol → (2,4-Dimethylthiophen-3-yl)methanol

HRID 127768Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 127768
[BH4-].[Na+].[CH3:3][C:4]1[S:5][CH:6]=[C:7]([CH3:11])[C:8]=1[CH:9]=[O:10].C(O)C>O>[CH3:3][C:4]1[S:5][CH:6]=[C:7]([CH3:11])[C:8]=1[CH2:9][OH:10]

Komponenten

5

Edukt 3

HCID 702EthanolHCID 4311764Sodium borohydrideHCID 111477702,4-Dimethylthiophene-3-carbaldehyde

Produkt 1

HCID 12875266(2,4-Dimethylthiophen-3-yl)methanol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

0.68 G. (18 mmol) of sodium borohydride was added in three portions to a solution of 10.88 g. (72 mmol) of 2,4-dimethylthiophene-3-carboxaldehyde in 120 ml. of ethanol. After 15 min., the reaction mixture was poured into water, extracted with ether, dried and the solvent evaporated. The resulting residue was recrystallized from hexane to yield 2,4-dimethyl-3-hydroxymethylthiophene, m.p. 80° C.

Aufarbeitung

  1. extractionextracted with ether
  2. customdried
  3. customthe solvent evaporated
  4. customThe resulting residue was recrystallized from hexane

Quellen und Nachweise

ORD-Eintrag
ord-91a96d1ed762426db09250a87c7df9fd
Quelldatensatz
uspto-grants-1981_03
Patentnummer
US04256878

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