3,4-dihydro-2H-pyran → 2-(5-Bromopentyloxy)tetrahydro-2H-pyran

HRID 127800

Reaktionsgleichung

Reaktionsgleichung von HRID 127800
[Br:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][OH:7].[O:8]1[CH:13]=[CH:12][CH2:11][CH2:10][CH2:9]1>P(Cl)(Cl)(Cl)=O.C(OCC)C>[Br:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][O:7][CH:9]1[CH2:10][CH2:11][CH2:12][CH2:13][O:8]1

Komponenten

5

Edukt 2

HCID 80803,4-dihydro-2H-pyranHCID 1187091-Pentanol, 5-bromo-

Produkt 1

HCID 27869332-(5-Bromopentyloxy)tetrahydro-2H-pyran

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 24813Phosphorus oxychlorideKatalysatorHCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

To 36 g of 5-bromopentan-1-ol were added 24.72 ml of 2,3-dihydropyran and 3 drops of phosphorus oxychloride under cooling in an ice bath, and the mixture was stirred overnight at room temperature. The reaction mixture was diluted with diethyl ether, washed with 5% aqueous potassium hydroxide, water, a saturated aqueous solution of sodium chloride, dried over magnesium sulphate and concentrated under reduced pressure. The residue was purified by column chromatography on silica gel using a mixture of ethyl acetate and hexane (1:19) as eluent to give 49.5 g of the subtitle compound having the following physical characteristics:

Aufarbeitung

  1. temperatureunder cooling in an ice bath
  2. washwashed with 5% aqueous potassium hydroxide, water
  3. dry with materiala saturated aqueous solution of sodium chloride, dried over magnesium sulphate
  4. concentrationconcentrated under reduced pressure
  5. customThe residue was purified by column chromatography on silica gel using
  6. additiona mixture of ethyl acetate and hexane (1:19) as eluent

Quellen und Nachweise

ORD-Eintrag
ord-a7b12ef579b64c6491bfc0e7afa3bd18
Quelldatensatz
uspto-grants-1981_03
Patentnummer
US04256757

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