Piperazine → 1-[2-(2,6-Dimethyl-phenoxy)ethyl]piperazine

HRID 128205

Reaktionsgleichung

Reaktionsgleichung von HRID 128205
[CH3:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]([CH3:12])[C:3]=1[O:4][CH2:5][CH2:6]Br.[I-].[Na+].C(=O)([O-])[O-].[K+].[K+].[NH:21]1[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1>CC(CC)=O>[CH3:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]([CH3:12])[C:3]=1[O:4][CH2:5][CH2:6][N:21]1[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1

Komponenten

6

Edukt 4

HCID 4837PiperazineHCID 5238Sodium IodideHCID 11430Potassium CarbonateHCID 24522082-(2-Bromoethoxy)-1,3-dimethylbenzene

Produkt 1

HCID 234686521-[2-(2,6-Dimethyl-phenoxy)ethyl]piperazine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6569Methyl Ethyl KetoneLösungsmittel

Versuchsvorschrift

To methylethylketone (1 liter) are added 2-(2,6-dimethylphenoxy)-1-bromo-ethane (132 g), sodium iodide (85 g), potassium carbonate (80 g) and piperazine (200 g). The mixture is refluxed for 24 hours, with stirring. After cooling, the mixture is filtered and then washed with 3×300 ml benzene. After evaporation of the benzene, the piperazine derivative is distilled; b.p. 25 mm Hg=190° C.

Aufarbeitung

  1. temperatureThe mixture is refluxed for 24 hours
  2. temperatureAfter cooling
  3. filtrationthe mixture is filtered
  4. washwashed with 3×300 ml benzene
  5. customAfter evaporation of the benzene
  6. distillationthe piperazine derivative is distilled
  7. customb.p. 25 mm Hg=190° C.

Quellen und Nachweise

ORD-Eintrag
ord-81ef5e212bdb488faab82b396a9fc6ad
Quelldatensatz
uspto-grants-1981_03
Patentnummer
US04259334

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