Monobenzone → 4-[4-(Trifluoromethoxy)-2-nitrophenoxy]-phenyl benzyl ether

HRID 128494

Reaktionsgleichung

Reaktionsgleichung von HRID 128494
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([OH:15])=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C[O-].[K+].[F:19][C:20]([F:33])([F:32])[O:21][C:22]1[CH:27]=[CH:26][C:25](Cl)=[C:24]([N+:29]([O-:31])=[O:30])[CH:23]=1>CN(C=O)C>[CH2:1]([O:8][C:9]1[CH:10]=[CH:11][C:12]([O:15][C:25]2[CH:26]=[CH:27][C:22]([O:21][C:20]([F:33])([F:19])[F:32])=[CH:23][C:24]=2[N+:29]([O-:31])=[O:30])=[CH:13][CH:14]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Komponenten

5

Edukt 3

HCID 7638MonobenzoneHCID 232972111-Chloro-2-nitro-4-(trifluoromethoxy)benzeneHCID 23664618Potassium methoxide

Produkt 1

HCID 234698274-[4-(Trifluoromethoxy)-2-nitrophenoxy]-phenyl benzyl ether

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

To a mixture of 10.01 g. of 4-(benzyloxy)phenol and 3.51 g. (0.05 mole) of potassium methoxide in 75 ml. of DMF is added 12.08 g. (0.05 mole) of 4-(trifluoromethoxy)-2-nitro-1-chlorobenzene. The mixture is heated to complete the reaction. Most of the solvent is removed at reduced pressure and the residue treated with methylene chloride and water. The methylene chloride solution is washed with saturated brine, dried, and the solvent removed, leaving 4-[4-(trifluoromethoxy)-2-nitrophenoxy]-phenyl benzyl ether.

Aufarbeitung

  1. additionTo a mixture of 10.01 g
  2. temperatureThe mixture is heated
  3. customthe reaction
  4. customMost of the solvent is removed at reduced pressure
  5. additionthe residue treated with methylene chloride and water
  6. washThe methylene chloride solution is washed with saturated brine
  7. customdried
  8. customthe solvent removed

Quellen und Nachweise

ORD-Eintrag
ord-1391ff6e4cd44424a79ed88c9d8f6738
Quelldatensatz
uspto-grants-1981_03
Patentnummer
US04259532

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