Acetic Acid → HCID 178476398, Verbindung
Reaktionsgleichung
[C:1]([OH:4])(=[O:3])[CH3:2].Br.C(OC([NH:16][C@H:17]([C:24]([N:26]1[CH2:36][CH2:35][CH2:34][C@H:27]1[C:28]([NH:30][CH2:31][CH2:32]O)=[O:29])=[O:25])[CH2:18][C:19]1[N:23]=[CH:22][NH:21][CH:20]=1)=O)C1C=CC=CC=1>CCOCC>[NH2:16][C@H:17]([C:24]([N:26]1[CH2:36][CH2:35][CH2:34][C@H:27]1[C:28]([NH:30][CH2:31][CH2:32][O:3][C:1](=[O:4])[CH3:2])=[O:29])=[O:25])[CH2:18][C:19]1[N:23]=[CH:22][NH:21][CH:20]=1Komponenten
5
Edukt 3
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
To 37.5 ml of ice-cooled acetic acid solution of 25% hydrobromic acid was added 3.22 g of compound (54) and the reaction was maintained for 3 hours at room temperature. The reaction mixture was added to 375 ml of dry ether and the precipitates thus formed were quickly collected by filtration and dried overnight in a desiccator containing potassium hydroxide to provide 4.43 g of L-histidyl-N-(2-acetoxyethyl)-L-prolinamide.2-hydrobromide.