6-[1-Oxo-4-(4-phenylpiperazinyl)-butyl]-3,4-dihydrocarbostyril → 6-[1-Hydroxy-4-(4-phenyl-1-piperazinyl)butyl]-3,4-dihydrocarbostyril

HRID 1285435Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1285435
[O:1]=[C:2]([C:18]1[CH:19]=[C:20]2[C:25](=[CH:26][CH:27]=1)[NH:24][C:23](=[O:28])[CH2:22][CH2:21]2)[CH2:3][CH2:4][CH2:5][N:6]1[CH2:11][CH2:10][N:9]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH2:8][CH2:7]1.[H][H]>O.[Pd]>[OH:1][CH:2]([C:18]1[CH:19]=[C:20]2[C:25](=[CH:26][CH:27]=1)[NH:24][C:23](=[O:28])[CH2:22][CH2:21]2)[CH2:3][CH2:4][CH2:5][N:6]1[CH2:7][CH2:8][N:9]([C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH2:10][CH2:11]1

Komponenten

5

Edukt 2

HCID 30670756-[1-Oxo-4-(4-phenylpiperazinyl)-butyl]-3,4-dihydrocarbostyrilHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 128335176-[1-Hydroxy-4-(4-phenyl-1-piperazinyl)butyl]-3,4-dihydrocarbostyril

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 962WaterLösungsmittel

Versuchsvorschrift

2.0 Grams of 6-[1-oxo-4-(4-phenylpiperazinyl)-butyl]-3,4-dihydrocarbostyril and 0.5 g of palladium black were dispersed in 80 ml of water and stirred at a room temperature under 2 atmospheric pressure of hydrogen gas for 5 hours. The reaction mixture was filtered for removing the palladium black and the mother liquor was concentrated under a reduced pressure and the residue thus obtained was crystallized from acetone and a small amount of ethanol. The crude crystals thus obtained were collected by filtration and recrystallized from isopropanol to obtain 1.5 g of 6-[1-hydroxy-4-(4-phenyl-1-piperazinyl)butyl]-3,4-dihydrocarbostyril in colorless needle like crystals.

Aufarbeitung

  1. filtrationThe reaction mixture was filtered
  2. customfor removing the palladium black
  3. concentrationthe mother liquor was concentrated under a reduced pressure
  4. customthe residue thus obtained
  5. customwas crystallized from acetone
  6. customThe crude crystals thus obtained
  7. filtrationwere collected by filtration
  8. customrecrystallized from isopropanol

Quellen und Nachweise

ORD-Eintrag
ord-6a8ae5a40a17469db004fa105c41dbfa
Quelldatensatz
uspto-grants-1986_01
Patentnummer
US04567187

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