Hydrochloric Acid → 4-(2-(Diethylamino)ethoxy)aniline

HRID 128620

Reaktionsgleichung

Reaktionsgleichung von HRID 128620
[CH2:1]([N:3]([CH2:6][CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([N+:15]([O-])=O)=[CH:11][CH:10]=1)[CH2:4][CH3:5])[CH3:2].Cl.[OH-].[Na+]>O>[CH2:1]([N:3]([CH2:6][CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([NH2:15])=[CH:11][CH:10]=1)[CH2:4][CH3:5])[CH3:2]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 88294Diethyl[2-(4-nitrophenoxy)ethyl]amine

Produkt 1

HCID 4189324-(2-(Diethylamino)ethoxy)aniline

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

N,N-Diethyl-2-(4-nitrophenoxy)ethylamine (4.0 g) (prepared by the method described in Helv. Chim. Acta. 1960, 43, 1971) was dissolved in IMS (70 ml), water (10 ml) and concentrated hydrochloric acid (2 ml). The mixture was boiled under reflux and then reduced iron powder (4.6 g) was carefully added in portions. The mixture was boiled under reflux for 7 hours then hot filtered. The filtrate was basified with 5M sodium hydroxide solution and then evaporated under reduced pressure. The residue was partitioned between water and ether. The organic layer was separated, dried and evaporated to give 4-[2-(N,N-diethylamino)ethoxy]aniline as an oil.

Aufarbeitung

  1. temperatureunder reflux
  2. temperatureunder reflux for 7 hours
  3. customevaporated under reduced pressure
  4. customThe residue was partitioned between water and ether
  5. customThe organic layer was separated
  6. customdried
  7. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-093748d8a4c444aba0ba587ee5938d8f
Quelldatensatz
uspto-grants-1995_11
Patentnummer
US05464781

Verknüpfte Notizen

Wird geladen…