4-(2-Chloro-2-cyanoethyl)benzoic acid → 4-(2-Cyanoethyl)benzoic acid

HRID 1287957Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1287957
Cl[CH:2]([C:13]#[N:14])[CH2:3][C:4]1[CH:12]=[CH:11][C:7]([C:8]([OH:10])=[O:9])=[CH:6][CH:5]=1>[Zn].C(O)(=O)C>[C:13]([CH2:2][CH2:3][C:4]1[CH:12]=[CH:11][C:7]([C:8]([OH:10])=[O:9])=[CH:6][CH:5]=1)#[N:14]

Komponenten

4

Edukt 1

HCID 508886404-(2-Chloro-2-cyanoethyl)benzoic acid

Produkt 1

HCID 198791964-(2-Cyanoethyl)benzoic acid

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23994ZincKatalysatorHCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

100 parts of zinc powder are gradually added to a solution of 209.5 parts of 4-(2-chloro-2-cyanoethyl) benzoic acid in 500 parts of glacial acetic acid. The temperature rises quickly up to reflux and is maintained for approximately 1 hour. The solution is filtered when hot so a to eliminate the insoluble matter, then the filtrate is diluted with 1000 parts of water and the precipitate formed is isolated. Thus 122 parts of 4-(2-cyanoethyl) benzoic acid are obtained. M.P.: 182° C.

Aufarbeitung

  1. temperatureto reflux
  2. temperatureis maintained for approximately 1 hour
  3. filtrationThe solution is filtered when hot so
  4. additionthe filtrate is diluted with 1000 parts of water
  5. customthe precipitate formed
  6. customis isolated

Quellen und Nachweise

ORD-Eintrag
ord-fd18203542204cbcac75390e6de83719
Quelldatensatz
uspto-grants-1976_10
Patentnummer
US03987027

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