Water → N-(2-phenoxypropyl) phenylacetamide

HRID 1288244

Reaktionsgleichung

Reaktionsgleichung von HRID 1288244
[O:1]([CH:8]([CH3:11])[CH2:9][NH2:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:12]1([CH2:18][C:19](Cl)=[O:20])[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.C(=O)([O-])[O-].[Na+].[Na+].O>C1C=CC=CC=1>[O:1]([CH:8]([CH3:11])[CH2:9][NH:10][C:19](=[O:20])[CH2:18][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Komponenten

6

Edukt 4

HCID 962WaterHCID 7679Phenylacetyl chlorideHCID 10340Sodium CarbonateHCID 37183552-Phenoxy-1-propanamine

Produkt 1

HCID 53982648N-(2-phenoxypropyl) phenylacetamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 241BenzeneLösungsmittel

Versuchsvorschrift

2-Phenoxypropylamine (4.6 g.) was added to a mixture of phenylacetyl chloride (4.6 g.) and anhydrous sodium carbonate (3.3 g.) in dry benzene (20 ml.); there was an exothermic reaction and effervescence. The mixture was heated to reflux for 1 hour, cooled, treated with water, and then shaken. The benzene layer was separated, dried over anhydrous sodium sulphate, filtered, and diluted with light petroleum (b.p. 60°-80°) to give pure N-(2-phenoxypropyl) phenylacetamide, m.p. 94°-96°.

Aufarbeitung

  1. customan exothermic reaction and effervescence
  2. temperatureThe mixture was heated
  3. temperatureto reflux for 1 hour
  4. temperaturecooled
  5. customThe benzene layer was separated
  6. dry with materialdried over anhydrous sodium sulphate
  7. filtrationfiltered
  8. additiondiluted with light petroleum (b.p. 60°-80°)

Quellen und Nachweise

ORD-Eintrag
ord-eb899a3290074f6d99f4f0b47022969c
Quelldatensatz
uspto-grants-1976_10
Patentnummer
US03987158

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