Sodium Acetate → HCID 2910222, Verbindung

HRID 1289158

Reaktionsgleichung

Reaktionsgleichung von HRID 1289158
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[CH2:9][O:10][C:11]1[CH:18]=[CH:17][C:14]([CH:15]=O)=[CH:13][CH:12]=1.C([O-])(=O)C.[Na+].[S:24]1[CH2:30][C:28](=[O:29])[NH:27][C:25]1=[S:26]>C(O)(=O)C>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[CH2:9][O:10][C:11]1[CH:18]=[CH:17][C:14]([CH:15]=[C:30]2[S:24][C:25](=[S:26])[NH:27][C:28]2=[O:29])=[CH:13][CH:12]=1

Komponenten

5

Edukt 3

HCID 517045Sodium AcetateHCID 7354674-[(2-Chloro-6-fluorophenyl)methoxy]benzaldehydeHCID 1201546Rhodanine

Produkt 1

HCID 2910222HCID 2910222, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

Under a nitrogen atmosphere in a round bottom flask 4-[(2-chloro-6-fluorophenyl)methoxy]benzaldehyde (1.00 g, 3.78 mmol) was dissolved in acetic acid (19 ml). To this solution was added sodium acetate (1.08 g, 13.2 mmol) and then rhodanine (0.50 g, 3.75 mmol). The reaction mixture was then heated to reflux and maintained at this temeprature. The progress of the reaction was monitored by thin layer chromatography.

Aufarbeitung

  1. temperatureThe reaction mixture was then heated
  2. temperatureto reflux
  3. temperaturemaintained at this temeprature

Quellen und Nachweise

ORD-Eintrag
ord-093ea1f308e842fbb0137430c1943964
Quelldatensatz
uspto-grants-1998_05
Patentnummer
US05747517

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