Water → (5-Chloro-3-(difluoromethyl)-1-methyl-1H-pyrazol-4-yl)methanol

Temperatur

0 °C

A solution of 7.2 g (37.0 mmoles) of 5-chloro-3-difluoromethyl-1-methyl-1H-pyrazole-4-carboaldehyde dissolved in 100 ml of methanol was cooled to 0° C. Thereto was gradually added 2.1 g (55.5 mmoles) of sodium borohydride. The mixture was stirred at room temperature for 3 hours to give rise to a reaction. After the completion of the reaction, the reaction mixture was poured into water, followed by extraction with ethyl acetate. The resulting organic layer was washed with an aqueous sodium chloride solution and then dried over anhydrous magnesium sulfate. The resulting solution was subjected to vacuum distillation to remove the solvent contained therein, to obtain 3.8 g (yield: 52.1%) of (5-chloro-3-difluoromethyl-1-methyl-1H-pyrazol-4-yl)-methanol.

1. customto give rise
2. customto a reaction
3. customAfter the completion of the reaction
4. extractionfollowed by extraction with ethyl acetate
5. washThe resulting organic layer was washed with an aqueous sodium chloride solution
6. dry with materialdried over anhydrous magnesium sulfate
7. distillationThe resulting solution was subjected to vacuum distillation
8. customto remove the solvent

ORD-Eintrag

ord-d6c664937e5a44c08ddea4cb267a9a43

Quelldatensatz

uspto-grants-2007_07

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US07238689B2