Water → (4-Ethoxy-6-trifluoromethylpyrimidin-5-yl)-methanol
Reaktionsgleichung
[CH2:1]([O:3][C:4]1[C:9]([CH:10]=[O:11])=[C:8]([C:12]([F:15])([F:14])[F:13])[N:7]=[CH:6][N:5]=1)[CH3:2].[BH4-].[Na+].O>CO>[CH2:1]([O:3][C:4]1[C:9]([CH2:10][OH:11])=[C:8]([C:12]([F:14])([F:15])[F:13])[N:7]=[CH:6][N:5]=1)[CH3:2]Komponenten
Edukt 3
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 0 °C
Versuchsvorschrift
A solution of 3.82 g (17.2 mmoles) of 4-ethoxy-6-trifluoromethylpyrimidine-5-carboaldehyde dissolved in 50 ml of methanol was added, with ice-cooling, to a solution of 1.7 g (45.7 mmoles) of sodium borohydride dissolved in 50 ml of methanol. The mixture was stirred at 0° C. for 1 hour to give rise to a reaction. After the completion of the reaction, the reaction mixture was poured into water, followed by extraction with ethyl acetate. The resulting organic layer was washed with an aqueous sodium chloride solution and then dried over anhydrous magnesium sulfate. The resulting solution was subjected to vacuum distillation to remove the solvent contained therein, to obtain 3.77 g (yield: 97.8%) of (4-ethoxy-6-trifluoromethylpyrimidin-5-yl)-methanol
Aufarbeitung
- additionwas added, with ice-
- customto give rise
- customto a reaction
- customAfter the completion of the reaction
- extractionfollowed by extraction with ethyl acetate
- washThe resulting organic layer was washed with an aqueous sodium chloride solution
- dry with materialdried over anhydrous magnesium sulfate
- distillationThe resulting solution was subjected to vacuum distillation
- customto remove the solvent
Quellen und Nachweise
- ORD-Eintrag
- ord-1dca1db12fec49bcb7ba804f9161aaab
- Quelldatensatz
- uspto-grants-2007_07
- Patentnummer
- US07238689B2
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