Water → 1-Tosylpyrozole

HRID 1293150

Reaktionsgleichung

Reaktionsgleichung von HRID 1293150
[NH:1]1[CH:5]=[CH:4][CH:3]=[N:2]1.[C:6]1([CH3:16])[CH:11]=[CH:10][C:9]([S:12](Cl)(=[O:14])=[O:13])=[CH:8][CH:7]=1.O>N1C=CC=CC=1>[C:6]1([CH3:16])[CH:11]=[CH:10][C:9]([S:12]([N:1]2[CH:5]=[CH:4][CH:3]=[N:2]2)(=[O:14])=[O:13])=[CH:8][CH:7]=1

Komponenten

5

Edukt 3

HCID 962WaterHCID 1048PyrazoleHCID 73974-Toluenesulfonyl chloride

Produkt 1

HCID 3207501-TosylpyrozoleAusbeute 15,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel

Reaktionsbedingungen

Temperatur
130 °C

Versuchsvorschrift

A suspension of pyrazole (1 g) and 4-toluenesulfonyl chloride (2.8 g) in pyridine (10 ml) was stirred at 130° C. for 1 hour. After the reaction mixture was cooled, water was added to the reaction mixture, resulting in a white suspension. The resultant suspension was filtered, and the obtained white solids were washed three times with water. Drying at room temperature under reduced pressure gave white solids (500 mg).

Aufarbeitung

  1. temperatureAfter the reaction mixture was cooled
  2. customresulting in a white suspension
  3. filtrationThe resultant suspension was filtered
  4. washthe obtained white solids were washed three times with water
  5. customDrying at room temperature under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-27d2bf1fc6a949e3be428f9784d16fe0
Quelldatensatz
uspto-grants-2007_07
Patentnummer
US07238720B2

Verknüpfte Notizen

Wird geladen…