Sodium Chloride → 3-(2,4,5-Trifluoro-phenoxy)propan-1-ol

HRID 1295720

Reaktionsgleichung

Reaktionsgleichung von HRID 1295720
[CH2:1]([OH:5])[CH2:2][CH2:3][OH:4].CC([O-])(C)C.[K+].[F:12][C:13]1[CH:18]=[C:17]([F:19])[C:16]([F:20])=[CH:15][C:14]=1F.[Cl-].[Na+]>O.C1(C)C=CC=CC=1.CS(C)=O>[F:12][C:13]1[CH:18]=[C:17]([F:19])[C:16]([F:20])=[CH:15][C:14]=1[O:4][CH2:3][CH2:2][CH2:1][OH:5]

Komponenten

8

Edukt 4

HCID 5234Sodium ChlorideHCID 94741,2,4,5-TetrafluorobenzeneHCID 104421,3-PropanediolHCID 23665647Potassium tert-butoxide

Produkt 1

HCID 693656313-(2,4,5-Trifluoro-phenoxy)propan-1-ol

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 679Dimethyl SulfoxideLösungsmittelHCID 962WaterLösungsmittelHCID 1140TolueneLösungsmittel

Versuchsvorschrift

To a mixture of 1,3-propanediol (15 g, 0.20 mol) and t-BuOK (8.0 g, 0.071 mol) were added 1,2,4,5-tetrafluorobenzene (5.0 g, 33 mol) and DMSO (50 g) at 60° C. After being stirred at this temperature for 18 h, toluene (200 mL), water (50 mL) and sodium chloride (10 g) were added to the reaction mixture. The layers were separated and the organic layer was concentrated in vacuo to the title compound that was used directly in the next step.

Aufarbeitung

  1. customThe layers were separated
  2. concentrationthe organic layer was concentrated in vacuo to the title compound that

Quellen und Nachweise

ORD-Eintrag
ord-04fab01c7dfb40d0b7ee845903b92f4c
Quelldatensatz
uspto-grants-2007_07
Patentnummer
US07244722B2

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