2-[(Benzylmethylamino)methyl]-1-pyridin-3-ylcyclohexanol hydrochloride → 2-Methylaminomethyl-1-pyridin-3-yl-cyclohexanol hydrochloride

HRID 131526Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 131526
[ClH:1].C([CH2:9][NH:10][CH2:11][CH:12]1[CH2:17][CH2:16][CH2:15][CH2:14][C:13]1([C:19]1[CH:20]=[N:21][CH:22]=[CH:23][CH:24]=1)[OH:18])C1C=CC=CC=1.[H][H]>C(O)(=O)C.[Pd]>[ClH:1].[CH3:9][NH:10][CH2:11][CH:12]1[CH2:17][CH2:16][CH2:15][CH2:14][C:13]1([C:19]1[CH:20]=[N:21][CH:22]=[CH:23][CH:24]=1)[OH:18]

Komponenten

5

Edukt 2

HCID 692216432-[(Benzylmethylamino)methyl]-1-pyridin-3-ylcyclohexanol hydrochlorideHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 692224012-Methylaminomethyl-1-pyridin-3-yl-cyclohexanol hydrochlorideAusbeute 75,2 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

11.1 g 2-[(benzylmethylamino)methyl]-1-pyridin-3-yl-cyclohexanol hydrochloride were dissolved in 110 ml glacial acetic acid under nitrogen, 2.0 g palladium-on-active charcoal (10 percent by weight) were added as a catalyst and the mixture was stirred under a hydrogen pressure of 2.0 bar until the uptake of hydrogen had ended. The mixture was filtered with suction, the filtrate was concentrated, the residue was stirred overnight with 75 ml isopropanol and the precipitate obtained was filtered off with suction and dried. 6.18 g 2-methylaminomethyl-1-pyridin-3-yl-cyclohexanol hydrochloride were obtained.

Aufarbeitung

  1. filtrationThe mixture was filtered with suction
  2. concentrationthe filtrate was concentrated
  3. customthe precipitate obtained
  4. filtrationwas filtered off with suction
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-8402a9c933c44beea814ede68bde611e
Quelldatensatz
uspto-grants-2008_06
Patentnummer
US07384961B2

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