2-Methyl-3-nitroaniline → 4-Iodo-2-methyl-3-nitrobenzenamine

HRID 132171

Reaktionsgleichung

Reaktionsgleichung von HRID 132171
[CH3:1][C:2]1[C:8]([N+:9]([O-:11])=[O:10])=[CH:7][CH:6]=[CH:5][C:3]=1[NH2:4].C(=O)([O-])O.[Na+].[I:17]Cl>CO>[I:17][C:7]1[CH:6]=[CH:5][C:3]([NH2:4])=[C:2]([CH3:1])[C:8]=1[N+:9]([O-:11])=[O:10]

Komponenten

5

Edukt 3

HCID 117832-Methyl-3-nitroanilineHCID 24640Iodine chlorideHCID 516892Sodium Bicarbonate

Produkt 1

HCID 597319804-Iodo-2-methyl-3-nitrobenzenamine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

To a well stirred solution of 2-methyl-3-nitroaniline (10 g, 66 mmol) in methanol (150 mL) was added sodium hydrogencarbonate (264 mmol) followed by 1.0 M solution of iodine monochloride (72 mmol) at room temperature. After stirring for 1 h, the solvent was removed, diluted with ether, washed with 10% aqueous sodium thiosulfate solution. The solvent was removed and the crude iodide was in the next step.

Aufarbeitung

  1. customthe solvent was removed
  2. additiondiluted with ether
  3. washwashed with 10% aqueous sodium thiosulfate solution
  4. customThe solvent was removed

Quellen und Nachweise

ORD-Eintrag
ord-33764736bfb34ca0a0ad535e78331c5d
Quelldatensatz
uspto-grants-2008_06
Patentnummer
US07384930B2

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