Potassium Carbonate → 5-(2-Cyano-phenoxy)-4-(6-methanesulfonyl-pyridin-3-yloxy)-2-nitro-phenylamine

HRID 13292

Reaktionsgleichung

[OH:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[C:4]#[N:5].C(=O)([O-])[O-].[K+].[K+].CN1CCCC1=O.F[C:24]1[C:25]([O:34][C:35]2[CH:36]=[N:37][C:38]([S:41]([CH3:44])(=[O:43])=[O:42])=[CH:39][CH:40]=2)=[CH:26][C:27]([N+:31]([O-:33])=[O:32])=[C:28]([NH2:30])[CH:29]=1>O>[C:4]([C:3]1[CH:6]=[CH:7][CH:8]=[CH:9][C:2]=1[O:1][C:24]1[C:25]([O:34][C:35]2[CH:36]=[N:37][C:38]([S:41]([CH3:44])(=[O:42])=[O:43])=[CH:39][CH:40]=2)=[CH:26][C:27]([N+:31]([O-:33])=[O:32])=[C:28]([NH2:30])[CH:29]=1)#[N:5]

Komponenten

Reaktionsbedingungen

Temperatur: 90 °C

Versuchsvorschrift

60 mg of 2-hydroxy-benzonitrile and 70 mg of potassium carbonate were added to an N-methylpyrrolidinone (2 ml) solution of 150 mg of 5-fluoro-4-(6-methanesulfonyl-pyridin-3-yloxy)-2-nitro-phenylamine obtained in (step 3), and the reaction liquid was stirred at 90° C. for 5 hours. Water was added to the reaction liquid, and the deposit was taken out through filtration to obtain the entitled compound.

Aufarbeitung

customobtained in (step 3)
customthe reaction liquid
filtrationthe deposit was taken out through filtration
customto obtain the entitled compound

Quellen und Nachweise

ORD-Eintrag: ord-2db017ca3f4142d080bb5cc0e86c3cf0
Quelldatensatz: uspto-grants-2010_06
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US07728025B2

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