2-Methyl-5-hydroxypyridine → 6-(1-Acetyl-5-methylpyrrolidin-2-yl)-5-((6-methylpyridin-3-yl)oxy)-2-pyridin-2-yl-1H-benzimidazole

HRID 13416

Reaktionsgleichung

Reaktionsgleichung von HRID 13416
[C:1]([N:4]1[CH:8]([CH3:9])[CH2:7][CH2:6][CH:5]1[C:10]1[C:15](F)=[CH:14][C:13]([NH:17][C:18]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][N:21]=2)=O)=[C:12]([N+:26]([O-])=O)[CH:11]=1)(=[O:3])[CH3:2].[CH3:29][C:30]1[N:35]=[CH:34][C:33]([OH:36])=[CH:32][CH:31]=1>>[C:1]([N:4]1[CH:8]([CH3:9])[CH2:7][CH2:6][CH:5]1[C:10]1[C:15]([O:36][C:33]2[CH:34]=[N:35][C:30]([CH3:29])=[CH:31][CH:32]=2)=[CH:14][C:13]2[N:17]=[C:18]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][N:21]=3)[NH:26][C:12]=2[CH:11]=1)(=[O:3])[CH3:2]

Komponenten

3

Edukt 2

HCID 142752-Methyl-5-hydroxypyridineHCID 23145552N-(4-(1-acetyl-5-methylpyrrolidin-2-yl)-5-fluoro-2-nitrophenyl)pyridine-2-carboxamide

Produkt 1

HCID 231451926-(1-Acetyl-5-methylpyrrolidin-2-yl)-5-((6-methylpyridin-3-yl)oxy)-2-pyridin-2-yl-1H-benzimidazole

Versuchsvorschrift

The entitled compound was obtained as a pale yellow solid in the same method as in Example 338 (step 5) or in accordance with the method or by combining it with an ordinary method but using N-(4-(1-acetyl-5-methylpyrrolidin-2-yl)-5-fluoro-2-nitrophenyl)pyridine-2-carboxamide obtained in Example 545 and 6-methylpyridin-3-ol.

Aufarbeitung

  1. customThe entitled compound was obtained as a pale yellow solid in the same method as in Example 338 (step 5) or in accordance with the method

Quellen und Nachweise

ORD-Eintrag
ord-e9a8116868f6419094ed6c0955c19366
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07728025B2

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