Lithium Hydroxide → 2-Hydroxy-2-methyl-N-(2,2,2-trifluoro-ethyl)-malonamic acid

HRID 1348654Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1348654
C([O:3][C:4](=[O:16])[C:5]([OH:15])([CH3:14])[C:6]([NH:8][CH2:9][C:10]([F:13])([F:12])[F:11])=[O:7])C.[OH-].[Li+]>O1CCCC1.O>[OH:15][C:5]([CH3:14])([C:6]([NH:8][CH2:9][C:10]([F:11])([F:12])[F:13])=[O:7])[C:4]([OH:16])=[O:3]

Komponenten

5

Edukt 2

HCID 3939Lithium HydroxideHCID 86605290HCID 86605290, Verbindung

Produkt 1

HCID 210914072-Hydroxy-2-methyl-N-(2,2,2-trifluoro-ethyl)-malonamic acidAusbeute 85 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To a solution of 3.60 g (15.0 mmol) (S or R)-2-hydroxy-2-methyl-N-(2,2,2-trifluoro-ethyl)-malonamic acid ethyl ester, entity A, in 50 ml of tetrahydrofurane were added 0.65 g (16 mmol) of lithium hydroxide in 25 ml of water and the mixture was stirred for 18 hours at room temperature. After removal of the organic solvent by distillation the mixture was acidified to pH 1. Extraction with ethylacetate gave 2.70 g (85%) of the title compound as an oil, MS m/e (%): 214.3 (M−H, 100).

Aufarbeitung

  1. customAfter removal of the organic solvent
  2. distillationby distillation the mixture
  3. extractionExtraction with ethylacetate

Quellen und Nachweise

ORD-Eintrag
ord-eca943983e924e3e8e723f3f96e2d01d
Quelldatensatz
uspto-grants-2007_05
Patentnummer
US07211573B2

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