Lithium Hydroxide → 2-Hydroxy-2-methyl-N-(2,2,2-trifluoro-ethyl)-malonamic acid

HRID 1348655Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1348655
C([O:3][C:4](=[O:16])[C:5]([OH:15])([CH3:14])[C:6]([NH:8][CH2:9][C:10]([F:13])([F:12])[F:11])=[O:7])C.[OH-].[Li+]>O1CCCC1.O>[OH:15][C:5]([CH3:14])([C:6]([NH:8][CH2:9][C:10]([F:11])([F:12])[F:13])=[O:7])[C:4]([OH:16])=[O:3]

Komponenten

5

Edukt 2

HCID 3939Lithium HydroxideHCID 86605290HCID 86605290, Verbindung

Produkt 1

HCID 210914072-Hydroxy-2-methyl-N-(2,2,2-trifluoro-ethyl)-malonamic acidAusbeute 89 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To a solution of 3.680 g (16.0 mmol) (S or R)-2-hydroxy-2-methyl-N-(2,2,2-trifluoro-ethyl)-malonamic acid ethyl ester, entity B. in 50 ml of tetrahydrofurane were added 0.69 g (16 mmol) of lithium hydroxide in 25 ml of water and the mixture was stirred for 18 hours at room temperature. After removal of the organic solvent by distillation the mixture was acidified to pH 1. Extraction with ethylacetate gave 3.00 g (89%) of the title compound as an oil, MS m/e (%): 213.9 (M−H, 100).

Aufarbeitung

  1. customAfter removal of the organic solvent
  2. distillationby distillation the mixture
  3. extractionExtraction with ethylacetate

Quellen und Nachweise

ORD-Eintrag
ord-aeb78cd11fae4c9984faa0b724c6e36c
Quelldatensatz
uspto-grants-2007_05
Patentnummer
US07211573B2

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