Lithium Hydroxide → 2-Hydroxy-2-methyl-N-(3,3,3-trifluoro-propyl)-malonamic acid

HRID 1348657Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1348657
C([O:3][C:4](=[O:17])[C:5]([OH:16])([CH3:15])[C:6]([NH:8][CH2:9][CH2:10][C:11]([F:14])([F:13])[F:12])=[O:7])C.[OH-].[Li+]>O1CCCC1.O>[OH:16][C:5]([CH3:15])([C:6]([NH:8][CH2:9][CH2:10][C:11]([F:12])([F:13])[F:14])=[O:7])[C:4]([OH:17])=[O:3]

Komponenten

5

Edukt 2

HCID 3939Lithium HydroxideHCID 86605291HCID 86605291, Verbindung

Produkt 1

HCID 210914092-Hydroxy-2-methyl-N-(3,3,3-trifluoro-propyl)-malonamic acidAusbeute 81 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To a solution of 2.30 g (7.87 mmol) 2-hydroxy-2-methyl-N-(3,3,3-trifluoro-propyl)-malonamic acid ethyl ester in 40 ml of tetrahydrofurane were added 0.33 g (7.87 mmol) of lithium hydroxide in 20 ml of water and the mixture was stirred overnight at room temperature. After concentration in vacuo water (50 ml) was added and the mixture was acidified to pH 1. Extraction with ethylacetate gave 1.46 g (81%) of the title compound as a solid, MS m/e (%): 228.1 (M−H, 100).

Aufarbeitung

  1. concentrationAfter concentration in vacuo water (50 ml)
  2. additionwas added
  3. extractionExtraction with ethylacetate

Quellen und Nachweise

ORD-Eintrag
ord-6597474e92504327b3675aec5733b99e
Quelldatensatz
uspto-grants-2007_05
Patentnummer
US07211573B2

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