Thiophenol → HCID 21100324, Verbindung

HRID 1352384Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1352384
I[CH:2]([CH3:8])[CH2:3][C:4]([F:7])([F:6])[F:5].[C:9]1([SH:15])[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O.CCOCC>[F:5][C:4]([F:7])([F:6])[CH2:3][CH:2]([S:15][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[CH3:8]

Komponenten

6

Edukt 3

HCID 7969ThiophenolHCID 11430Potassium CarbonateHCID 5738733-Iodo-1,1,1-trifluorobutane

Produkt 1

HCID 21100324HCID 21100324, VerbindungAusbeute 79 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 3283Diethyl EtherLösungsmittelHCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

To a solution of 54.9 mmol 3-iodo-1,1,1-trifluorobutane in 50 ml N,N-dimethylformamide were added 49.9 mmol thiophenol and 74.9 mmol potassium carbonate. The mixture was ultrasonicated at room temperature for 90 min. The reaction mixture was then diluted with ether and was washed three times with water. The organic phase was dried over sodium sulfate and concentrated in vacuo to afford the title compound as a colourless oil (yield 79%). MS (m/e): 221.3 (M+, 15%).

Aufarbeitung

  1. customThe mixture was ultrasonicated at room temperature for 90 min
  2. washwas washed three times with water
  3. dry with materialThe organic phase was dried over sodium sulfate
  4. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-45ca531e5a9b450790c87a223523ae67
Quelldatensatz
uspto-grants-2007_05
Patentnummer
US07220744B2

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